RAF Typhoon jets have operated alongside French aircraft in a combined operation on an subterranean weapons facility in Syria employed by the IS group, per a report from the UK's MoD.
The site, located using surveillance, was believed to be housing weapons and explosive materials, the statement said, and was positioned in hills just above the historic site of Palmyra in the heart of Syria.
"Our aircraft employed laser-guided Paveway IV weapons to hit a several entry passages down to the facility... early reports indicate the target was engaged successfully," the MoD said.
There was no sign of any civilian impact in the operation conducted Saturday night and every plane involved made a safe return, the MoD added.
The Typhoon fighters were backed up by a Voyager tanker plane.
The Islamic State group - referred to as ISIS - enforced jihadist rule over parts of Iraq and Syria before its territorial defeat in 2019.
"This action shows British leadership, and commitment to work closely with allied nations, to eradicate any resurgence of Daesh and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the minister said.
RAF aircraft have carried out overwatch operations over Syrian airspace to "prevent any attempted comeback" of the group following its military defeat at the battle of Baghuz in 2019, the authorities noted.
"I must thank every member of our armed forces participating in this mission for their expertise and their valour," the Defence Secretary added. "They were among thousands of British troops deployed over Christmas and New Year. This action, to remove dangerous terrorists who threaten our security, highlights how UK forces are ready to step up, continuously, ensuring Britain's security at home and strong abroad."
In December, the US military executed what it called a "large-scale strike" against Daesh sites in the country, after an assault resulted in the deaths of two US servicemembers and a civilian interpreter in the Palmyra area.
The U.N. reports IS still boasts an estimated 5,000 to 7,000 militants in Syria and Iraq.